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Hallucinogens and Psychedelics

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...

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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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血清醇类迷幻DOI会损害听觉皮层中偏差检测的功能.

Max Horrocks¹, Jennifer L Mohn¹, Santiago Jaramillo¹

¹Institute of Neuroscience, University of Oregon. Eugene, OR 97403.

bioRxiv : the preprint server for biology

|September 24, 2024

概括

像DOI这样的迷幻药物通过增加神经反应的可变性和减少对意想不到的声音的敏感性来改变听觉皮层功能. 这会影响大脑在迷幻体验期间如何处理听觉信息.

科学领域:

神经科学是一个神经科学.
心理药理学心理药理学
听觉神经科学听觉神经科学

背景情况:

迷幻药会引起感知变化,但听觉系统中的神经机制尚不清楚.
血清素2A受体是迷幻化合物的关键目标.
听觉皮层处理声音信息,包括调节频率和检测意外事件.

研究的目的:

调查迷幻2,5-Dimethoxy-4-iodoamphetamine (DOI) 如何影响听觉皮层神经元活动.
检查DOI对声音频率调整,神经响应可变性和偏差检测的影响.
阐明心理诱导的听觉改变背后的神经机制.

主要方法:

给药DOI (血清素2A受体激动剂) 唤醒小鼠.
在听觉皮层记录神经活动.
分析神经元对听觉刺激的反应,重点关注频率调节,响应变化和偏差检测.

主要成果:

DOI并没有持续改变听觉皮层神经元频率选择性.
DOI增加了神经反应的试验逐试验变化.
DOI减少了标准和奇怪的听觉刺激之间的神经区分,减少了偏差检测.

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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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结论:

DOI会抑制听觉皮层检测出意想不到的听觉事件的能力.
迷幻药物通过改变听觉皮层中神经反应动态来破坏感官处理.
研究结果提供了关于在迷幻药物下改变听觉感知的神经基础的见解.