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纵向多原子免疫分析揭示了健康成年人与年龄相关的免疫细胞动态

Qiuyu Gong¹, Mehul Sharma¹, Emma L Kuan¹

¹Allen Institute for Immunology, Seattle, WA, USA.

bioRxiv : the preprint server for biology

|September 24, 2024

概括

衰老会影响免疫系统,T细胞比其他细胞表现出更多与年龄有关的变化. 老年人表现出与CD4 T细胞转移相关的B细胞反应受损,揭示了衰老的免疫失调.

科学领域:

免疫学免疫学免疫学
老年学是指老年学的学科.
系统生物学系统生物学

背景情况:

免疫系统的功能在人类一生中会发生变化.
了解与年龄相关的免疫变化对于对抗老年人感染和疾病至关重要.
健康的衰老涉及到由宿主环境相互作用影响的动态免疫系统变化.

研究的目的:

为了研究人类外周免疫力与年龄相关的变化.
分析免疫细胞组成和转录状态在不同年龄段的恒温和疫苗反应期间.
确定在健康衰老中免疫失调背后的分子机制.

主要方法:

多原子分析包括单细胞RNA测序 (scRNA-seq),蛋白质组学和流细胞计.
对300多名健康成年人的外周血液单核细胞 (PBMC) 的分析.
在两年内对96名年轻人和老年人进行长度研究,每年接种疫苗.

主要成果:

不管炎症如何,T细胞都会积累与年龄相关的转录变化.
老年人表现出对疫苗接种的B细胞反应的记忆受损.
记忆CD4T细胞的Th2类状态转变与老年人B细胞反应受损有关.

结论:

人类免疫系统表现出与年龄相关的显著转录变化,特别是在T细胞中.
与衰老相关的免疫失调涉及T细胞种群的变化,影响B细胞反应.
免疫健康地图集为研究整个生命周期的免疫动态提供了宝贵的资源.

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