相关实验视频

Updated: May 13, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K

自闭症和智力障碍相关的MYT1L突变改变了人类皮层内部神经元的分化,成熟和生理学

Ramachandran Prakasam, Julianna Determan, Mishka Narasimhan

    bioRxiv : the preprint server for biology
    |September 24, 2024
    PubMed
    概括

    致病性MYT1L突变会损害人类内部神经元的发育和功能,揭示了神经发育障碍的洞察力. 这项研究使用人类干细胞来模拟MYT1L在大脑发育中的作用.

    更多相关视频

    Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs10:47

    Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

    Published on: March 2, 2018

    10.0K
    Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein10:59

    Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

    Published on: June 6, 2025

    142

    相关概念视频

    Long-term Potentiation01:35

    Long-term Potentiation

    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
    Long-term Potentiation01:25

    Long-term Potentiation

    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
    Hebbian LTP
    LTP can occur when presynaptic neurons...
    Forced Transdifferentiation01:28

    Forced Transdifferentiation

    Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
    Artificial transdifferentiation occurs...
    Disorders of the Nervous Tissue01:28

    Disorders of the Nervous Tissue

    Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
    Homeostatic Imbalances:
    Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
    Parkinson's disease arises from the...
    Neuroplasticity01:01

    Neuroplasticity

    Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
    Human Genetics01:28

    Human Genetics

    Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
    The complex relationship between genetics and psychology is observable through common biological components such...