作用于复杂特征的自然选择阻碍了古老样本中多基因分数的预测准确性
Valeria Añorve-Garibay1,2, Emilia Huerta-Sanchez1,3, Mashaal Sohail4
1Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA.
bioRxiv : the preprint server for biology
|September 24, 2024
概括
自然选择显著影响使用多基因分数预测古代人类特征的准确性. 稳定和定向选择都改变了等位基因的频率,降低了这些遗传预测的可靠性.
科学领域:
- 古遗传学是古遗传学的一部分.
- 进化遗传学的进化遗传学
- 定量遗传学 是一种定量遗传学.
背景情况:
- 古代人类的表型预测对于理解复杂的特征进化至关重要.
- 多基因分数,来自全基因组关联研究 (GWAS),通常用于这些预测.
- 进化过程可以在预测古代表型时引入偏见.
研究的目的:
- 通过使用多基因分数,研究自然选择对古代个体表型预测的影响.
- 分析不同选择模式 (中性,稳定,定向) 如何影响预测准确性.
- 评估自然选择对与古代特征预测相关的等位基因频率模式的影响.
主要方法:
- 在中性,稳定选择和方向选择下对添加性特征的模拟.
- 对等位基频率变化及其对多基因分数准确性影响的分析.
- 包括对身高和体重指数的现实选择强度和遗传性估计.
主要成果:
- 稳定性选择加快了大效应等位基因的丧失,而定向性选择则删除了驱使表型远离最佳的等位基因.
- 这些选择压力在古代和现代人群之间创造了独特的遗传变异模式.
- 自然选择显然阻碍了多基因分数用于预测古代表型的准确性.
结论:
- 自然选择显著降低了用于古代表型预测的多基因分数的可靠性.
- 了解进化影响对于准确的古遗传特征重建至关重要.
- 未来的研究必须考虑自然选择对古代人口遗传变异的影响.
更多相关视频
相关概念视频
Limits to Natural Selection
31.2K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
31.2K
Natural Selection and Adaptation
183
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
Beyond physical adaptations,...
183
Polygenic Traits
65.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.6K
Genetic Drift
39.6K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.6K
Gene Evolution - Fast or Slow?
7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.0K
Natural Selection and Mating Preferences
98
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
Females, due to their biological roles in conception, pregnancy, and nursing,...
98


