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跨物种大脑范围的映射揭示了NAc DBS参与的保存和协调网络

Austin Y Feng, Daniel A N Barbosa, Austen B Casey

bioRxiv : the preprint server for biology

|September 24, 2024

概括

核心突 (NAc) 的深度大脑刺激 (DBS) 激活了一个中皮层临网络. 这项研究揭示了跨物种的神经连接的保护,为神经精神疾病的NAc DBS机制提供了洞察力.

科学领域:

神经科学是一个神经科学.
神经调节是一种神经调节.
系统神经科学系统神经科学

背景情况:

核心心脏 (NAc) 的深度大脑刺激 (DBS) 是对耐火性神经精神疾病的有希望的治疗方法.
了解NAc DBS调节的神经网络对于阐明其治疗机制至关重要.
中皮层临回路在奖励和动机方面发挥着关键作用,使其成为神经调节的目标.

研究的目的:

为了绘制NAc DBS参与的大脑全神经活动的地图.
在物种中识别NAc DBS调节的保存的神经通路.
为神经精神疾病提供NAc DBS的机制性理解.

主要方法:

在小鼠中进行全脑清除和神经活动映射.
人类的内电生理学记录.
激发同源的中皮层临床节点.

主要成果:

在小鼠中,NAc DBS在协调的中皮层临网络中增加了神经活动.
在小鼠模型和人类NAc DBS之间观察到类似的连接模式.
鉴定了在中皮层临回路内的特定保存连接性.

结论:

NAc DBS调节了一个特定的,保存的中皮层临网络.
这些发现确定了在神经精神疾病中NAc DBS疗效的潜在机制.
该研究强调了动物模型对人类神经调节疗法的翻译相关性.

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