在伊拉克南部巴斯拉的成年人中可能存在异构性高胆固醇血症
Elaf A Khamees1, Nassar T Alibrahim2, Abbas A Mansour2
1Pathology, Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC), University of Basrah, Basrah, IRQ.
Cureus
|September 24, 2024
概括
家族性高胆固醇血症 (FH) 是一种常见的遗传性疾病. 这项研究发现,在伊拉克巴斯拉市,6.9%的成年人患有高LDL-C,这表明可能的FH和查和治疗的需要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 家族性高胆固醇血症 (FH) 是一种流行,自体主导的遗传性疾病.
- 较高的低密度脂蛋白胆固醇 (LDL-C) 水平可以表明可能的异性家族性高胆固醇血症 (HeFH).
研究的目的:
- 在伊拉克巴斯拉的成年人中确定LDL-C升高 (≥190毫克/分升) 的患病率.
- 为了确定HeFH的潜在病例,并为公共卫生战略提供信息.
主要方法:
- 从2008年8月到2023年12月对59,026名成年患者 (≥18岁) 的回顾性分析.
- 纳入标准:禁食的LDL-C≥190 mg/dL.
- 数据来自Faiha专门糖尿病,内分泌和新陈代谢中心 (FDEMC).
主要成果:
- 6.9%的人 (4,093/59,026) 的LDL-C≥190 mg/dL.
- 高峰年龄组是40-59岁 (51.7%).
- 女性 (58.8%) 和糖尿病患者 (71.7%) 占主导地位. 增加的LDL-C在女性 (69.6%) 和糖尿病患者 (84.1%) 中更为常见.
结论:
- 巴斯拉可能存在的HeFH的流行程度要求提高认识和有针对性的查计划.
- 研究结果强调,需要更广泛地获得降脂疗法.
- 建议进行进一步的遗传研究来确认FH,并探索基于性别和年龄的流行率差异.
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