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对腹膜内皮质提伊科普拉宁度与腹膜透析相关腹膜炎治疗结果之间的相关性进行调查

Lulu Wang^1,2, Jiangqing Fan³, Xuejie Chen⁴

¹Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Frontiers in pharmacology

|September 24, 2024

概括

腹膜透析相关腹膜炎 (PDAP) 用腹膜内 teicoplanin 治疗显示 88.9% 的疗效. 在第五天达到腹腔透析废水中提科普拉宁度超过15.138 mg/L对于成功控制PDAP患者的感染至关重要.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

腹膜透析相关的腹膜炎 (PDAP) 是腹膜透析 (PD) 的常见并发症.
国际腹腔透析协会 (ISPD) 的指导方针建议对PDAP进行腹腔内 teicoplanin,但没有定义最佳腹腔透析废水 (PDE) 度.

研究的目的:

评估腹腔内提克洛普拉宁在治疗PDAP时的疗效.
为了确定PDE teicoplanin度和治疗结果之间的关系.
为了确定影响PDE teicoplanin度的因素.

主要方法:

一项自我控制的研究招募了PDAP患者,这些患者接受了腹腔内 teicoplanin.
收集的数据包括PDE参数,临床症状,炎症标志物,药物不良反应 (ADRs) 和不同时间点的teicoplanin度 (血液和PDE).
患者被分为治愈和未治愈的组,以分析治疗的有效性和影响因素.

主要成果:

腹腔内提克洛普拉宁达到88.9%的疗效率,ADR发生率为5.5%.
在治愈后的组中,在第1,3,5和第7天观察到更高的PDE提科普拉宁度.
在第五天的PDE提伊科普拉宁度>15.138 mg/L与更高的治愈概率有关.
24小时尿量和每日PD会话影响了第5天的PDE提伊科普拉宁度.

结论:

内提克洛普拉宁在治疗PDAP方面是有效的,较高的PDE度与更好的结果相关.
监测PDE提伊科普拉宁度,特别是超过15.138 mg/L的第5天,可以指导有效的感染控制.
尿量和透析频率等因素会影响药物度和治疗成功.

关键词:

个性化药物治疗是个性化的药物治疗.腹膜透析的废水来自腹膜透析.腹膜透析相关的腹膜炎泰科普拉尼尼泰科普拉尼尼治疗药物监测治疗药物监测

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