在SARS-CoV-2感染后的行政人员赤字:一个横截面人口研究
S Buer1,2, B I Hagen1, A Søraas3
1Department of Research, Lovisenberg Diaconal Hospital, Oslo, Norway.
Brain, behavior, & immunity - health
|September 24, 2024
概括
与未感染的个体相比,感染SARS-CoV-2的个体报告了更多的执行功能缺陷,特别是在元认知和工作记忆方面. 这些认知挑战在感染后的6-12个月内持续存在.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 认知心理学 认知心理学
背景情况:
- 执行职能缺陷对日常生活产生重大影响.
- SARS-CoV-2 感染 (PASC) 后急性后果需要使用标准化的执行功能措施进行进一步调查.
- 有限的研究存在于特定于SARS-CoV-2感染的执行功能缺陷.
研究的目的:
- 为了确定SARS-CoV-2感染是否与执行功能缺陷有关.
- 为了调查SARS-CoV-2感染后执行功能缺陷的持续时间.
主要方法:
- 采用挪威Covid-19队列数据的横截面研究.
- 8102名参与者完成了执行功能-成人版本 (BRIEF-A) 的行为评级清单.
- 4183名参与者与之前的SARS-CoV-2 PCR和3919个未经测试或负的PCR对照进行了比较.
主要成果:
- 感染SARS-CoV-2的积极参与者比对照人群 (383人对225人) 更频繁地报告了临床值以上的执行缺陷.
- 超认知缺陷,特别是工作记忆,在SARS-CoV-2组中明显更为普遍.
- 调整后的分析显示,在感染后6-12个月,执行力缺陷的几率显著更高 (OR 1.97;95% CI 1.51-2.55).
结论:
- 这项研究证实SARS-CoV-2感染后感知到的执行力缺陷增加,而代认知功能受到影响最大.
- 这些发现突出了SARS-CoV-2感染后急性阶段潜在的功能困难.
- 结果可以为执行功能和元认知领域开发有针对性的干预措施提供信息.
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