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相关概念视频

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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相关实验视频

Updated: Jun 12, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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单疗或组合疗法在PsA:当前方面.

Elpida Skouvaklidou1, Paraskevi Avgerou1, Konstantinos D Vassilakis2

  • 1Department of Rheumatology, Fourth Department of Internal Medicine, Hippokration Hospital, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Greece.

Therapeutic advances in musculoskeletal disease
|September 24, 2024
PubMed
概括

本综述研究了结合常规疾病修饰性抗风湿药物 (DMARDs) 与生物DMARDs (bDMARDs) 或针对性合成DMARDs (tsDMARDs) 治疗牛皮关节炎 (PsA). 它评估了关于这种PSA患者组合治疗策略的有限数据.

关键词:
bDMARDs 的使用情况.组合疗法治疗组合治疗.csDMARDs 的使用情况.牛皮关节炎 牛皮关节炎这是DMARDs.

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科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 牛皮关节炎 (PsA) 是一种复杂的免疫媒介疾病,影响皮肤和关节.
  • 由于异质性,肌肉骨外问题和并发症,PsA管理具有挑战性.
  • 有许多治疗方法,包括传统的合成,生物和向的合成DMARDs.

研究的目的:

  • 审查关于PSA联合治疗的现有数据.
  • 评估将传统的DMARD与bDMARD或tsDMARD结合使用的疗效和安全性.
  • 与类风湿性关节炎相比,解决PsA中这种策略的证据稀缺问题.

主要方法:

  • 随机临床试验的系统审查.
  • 观察性研究的分析.
  • 包括来自患者登记册的数据.

主要成果:

  • 总结了关于PsA联合治疗的当前证据.
  • 突出了与类风湿性关节炎相比有限的数据.
  • 介绍了来自临床试验,观察研究和注册表的研究结果.

结论:

  • 在PsA中使用常规DMARD和bDMARD/tsDMARD的组合疗法需要进一步调查.
  • 该审查巩固了现有证据,以指导未来的研究和临床实践.
  • 需要更多的数据来确定这种治疗策略对PSA患者的价值.