在年轻人中估计球膜过率
Pierre Delanaye1,2, Laurence Derain-Dubourg3, Jonas Björk4,5
1Department of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium.
Clinical kidney journal
|September 24, 2024
概括
欧洲功能联盟 (EKFC) 和重新表达的隆德-马尔默修订式 (r-LMR) 方程比CKD-EPI方程更好地估计年轻成年人的球过率 (eGFR). 这一发现适用于大多数年轻人,但在过的情况下可能会有例外.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 基于肌素的方程是估计淋巴膜过率 (eGFR) 的标准.
- 关键的方程包括慢性病流行病学协作 (CKD-EPI),重新表达的隆德-马尔默修订 (r-LMR) 和欧洲功能联盟 (EKFC).
- 在年轻成年人中,EKFC和r-LMR的表现受到争议.
研究的目的:
- 为了比较EKFC,r-LMR和CKD-EPI方程在年轻成年人中估计GFR的性能.
- 为了确定EKFC和r-LMR是否在这个人口群体中提供了更好的准确性.
主要方法:
- 分析了来自欧洲和美国的2366名年轻成年人 (18-25岁) 的数据.
- 测量GFR (外源标记清除率) 作为参考方法.
- 血清肌素,年龄和性别被用于eGFR计算.
主要成果:
- 在欧洲队列中,EKFC和r-LMR比CKD-EPI显示出明显更好的偏差和准确性 (P30).
- 在美国非黑人队列中,EKFC和r-LMR也与CKD-EPI相比显示出更好的偏差.
- 在美国黑人个体中,表现差异不那么明显,而在P30的美国队列中,整体而言,表现差异不大. 在过中,CKD-EPI可能更准确.
结论:
- 在年轻人群中,EKFC和r-LMR基于肌素的方程式与CKD-EPI相比,表现优越.
- 这些发现表明,EKFC和r-LMR在这个年龄组的eGFR估计中更可靠.
- 对于经历过度过的个体可能存在例外,其中CKD-EPI可能是可取的.
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