多omics分析揭示了宿主-菌体微生物群相互作用对山羊模型生长表现的影响
Juncai Chen1, Xiaoli Zhang1, Xuan Chang1
1College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China.
Frontiers in microbiology
|September 24, 2024
概括
羊皮微生物群,尤其是羊皮表皮细菌,会影响山羊的生长速度. 高生长的山羊表现出更好的发酵和屏障功能,与特定的细菌群体相关,如Lachnospiraceae和Oscillospiraceae NK4A214.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 体微生物对于反动物的生长和健康至关重要.
- 皮表皮细菌在早期生长中的特定作用尚不清楚.
研究的目的:
- 研究不同生长速率的山羊的起草体发酵,微生物群和基因表达.
- 确定影响生命早期生长的关键微生物和宿主因素.
主要方法:
- 分析了6个月大的山羊的肠发酵模式,微生物群组成 (细菌和真菌) 和肠上皮的基因表达.
- 利用转录组分析和相关性分析将微生物和宿主因素与生长率联系起来.
主要成果:
- 高平均每日增益 (HADG) 的山羊具有更高的酸盐;低平均每日增益 (LADG) 的山羊具有明显的皮表皮细菌 (U29-B03,Quinella,Lachnospiraceae UCG-009).
- 液细菌 (Alloprevotella,Desulfovibrio) 和真菌 (Symmetrospora) 的丰度在生长组之间有所不同.
- 基因表达分析揭示了细胞结合和粘附途径的差异表达;特定的细菌与生长和屏障功能基因相关.
结论:
- 乳液微生物群,特别是乳液表皮细菌 (Lachnospiraceae,Oscillospiraceae NK4A214),有助于提高HADG山羊的乳液发酵效率.
- 改善膜上皮屏障功能和增强的短链脂肪酸 (SCFA) 运输与有利的微生物群组成有关.
- 体中的微生物群与宿主相互作用是年轻反动物早期生长表现的关键驱动因素.
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