心脏移植后的恶性瘤
Caroline Stenman1, Andreas Wallinder1,2, Erik Holmberg3,4
1Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
概括
心脏移植接受者面临的癌症风险明显更高,与普通人群相比,风险增加了6.2倍. 除非非黑色素瘤性皮肤癌外,风险仍然高,为2.9倍.
科学领域:
- 移植医学 移植医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 心脏移植 (HTx) 接受者已知患癌症的风险增加.
- 长期监测对于治疗移植后并发症至关重要.
研究的目的:
- 量化心脏移植接受者的癌症风险.
- 为了确定HTx后不同类型癌症的特定风险因素.
- 为了比较先前有癌症史和没有癌症史的HTx患者的生存结果.
主要方法:
- 对664名心脏移植患者 (1985-2017年) 的回顾性队列研究.
- 通过瑞典癌症登记处和死亡原因登记处识别的癌症诊断.
- 随访时间中位数为7.7年,分析了癌症发病率和存活率.
主要成果:
- 19%的HTx接受者在随访期间患上了癌症.
- 癌症的标准化发病率 (SIR) 比一般人群高6.2倍 (2.9倍不包括NMSC).
- 常见的恶性瘤包括NMSC,非霍奇金淋巴瘤和肺癌. 风险因素因癌症类型而异.
结论:
- 心脏移植与恶性瘤的风险大大增加有关.
- 确定特定的风险因素可以帮助针对HTx患者制定有针对性的癌症预防策略.
- 以前的癌症史没有显著影响选择的HTx接受者的整体存活率.
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