人类乳头瘤病毒相关的鼻癌:系统性审查和元分析
Brian Y Zhao1, Shun Hirayama1, Deborah Goss1
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts.
medRxiv : the preprint server for health sciences
|September 24, 2024
概括
人类乳头瘤病毒 (HPV) 是鼻癌 (NPC) 的一个因素,特别是在北美. 这次审查发现,全球HPV+NPC流行率为18%,北美比亚洲的发病率更高.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 人类乳头瘤病毒 (HPV) 被认为会影响头部和部部位,包括鼻.
- 与HPV相关的鼻癌 (HPV+NPC) 没有很好的特征,特别是其在非流行地区的流行率.
研究的目的:
- 为了确定HPV在鼻癌 (NPC) 的全球点患病率.
- 根据地理区域对NPC中的HPV流行情况进行分层.
主要方法:
- 在EMBASE,OVID Medline和Web of Science的系统文献搜索1990年至2022年间发表的研究.
- 包括46项研究,包括6314名NPC患者,遵循PRISMA指南.
- 分析HPV流行率估计,按地区分层,并确定占主导地位的HPV基因型.
主要成果:
- 全球HPV+NPC的患病率为18% (95%CI为0.14-0.23). 在全球范围内,HPV+NPC的患病率为18% (95%CI为0.14-0.23).
- 在北美 (25%) 的流行率最高,在亚洲 (13%) 的流行率最低.
- 在HPV+NPC中,HPV 16 (44%) 和HPV 18 (33%) 是最常见的基因型.
结论:
- 这一系统性审查和元分析提供了HPV+NPC的关键全球和区域流行数据.
- 研究结果表明,HPV是NPC的重要病因因素,特别是在北美.
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