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免疫细胞密度预测了在头癌中对免疫检查点阻塞的反应

Daniel A Ruiz-Torres1,2,3, Michael E Bryan1,2, Shun Hirayama1,2

  • 1Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA.

medRxiv : the preprint server for health sciences
|September 24, 2024
PubMed
概括

三级淋巴细胞结构 (TLS) 在响应免疫检查点阻塞 (ICB) 的头支状细胞癌 (HNSCC) 患者中更为普遍. TLS密度预测了ICB反应和生存,可能会超过PD-L1综合阳性得分 (CPS).

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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