在发育过程中对空气污染暴露和大脑结构和功能进行系统审查
Jessica Morrel1,2, Michelle Dong3, Michael A Rosario1
1Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
medRxiv : the preprint server for health sciences
|September 24, 2024
概括
暴露于室外空气污染与儿童和青少年的大脑变化有关. 这一更新的综述显示,更多的研究证实了这些影响,突出了关键的公共卫生问题.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 空气污染物是影响大脑发育的已知的神经毒素.
- 之前的系统审查已经强调了对空气污染对年轻大脑的影响的担忧.
研究的目的:
- 系统地审查和评估有关户外空气污染暴露及其对儿童和青少年大脑结构和功能的影响的新证据.
- 更新2019年系统审查的调查结果.
主要方法:
- 更新了PubMed和Web of Science的文献搜索,直到2024年3月.
- 包括14项新研究,共计20篇出版物,包括偏见风险评估.
- 利用各种磁共振成像 (MRI) 模式来评估大脑结构和功能.
主要成果:
- 暴露于空气污染物与儿童和青少年大脑的广泛差异有关.
- 调查结果包括跨越怀孕到青春期早期的研究.
- 在影响的大小和方向上发现了不一致性,限制了强有力的结论.
结论:
- 产前和儿童暴露于室外空气污染与结构和功能大脑变异有关.
- 自2019年以来,出版物数量翻了一番,这凸显了公共卫生的重要性.
- 需要进一步的研究,以了解发育时间效应和对认知和心理健康的影响.
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