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在临床怀疑的血清阴性自身免疫性相关症中改变了细胞因子概况

Katherine Motovilov¹, Cole Maguire¹, Deborah Briggs¹

¹The University of Texas at Austin, Department of Neurology.

medRxiv : the preprint server for health sciences

|September 24, 2024

概括

血清阴性自身免疫相关 (snAAE) 是一种耐药性的形式. 细胞因子分析,而不是自身抗体查,对诊断snAAE和指导免疫治疗有希望.

科学领域:

神经免疫学神经免疫学
发病学 (Epileptology) 是一个专业的学科.
生物标志物发现发现

背景情况:

自免疫相关 (AAE) 是一种日益增长的耐药性的原因,通常用免疫疗法治疗.
目前的诊断依赖于检测神经元自身抗体,缺失的病例,如对治疗有反应的血清阴性AAE (snAAE).
确定snAAE的生物标志物对于准确的诊断和有效的治疗至关重要.

研究的目的:

为了确定snAAE.新型诊断生物标志物.
为了比较snAAE,抗发作药物 (ASM) 反应性和其他神经炎症疾病中的细胞因子和自身抗体概况.

主要方法:

在患者队伍中对细胞因子和自身抗体进行全面分析.
在snAAE,ASM反应性和神经炎症疾病组之间比较生物标志物概况.

主要成果:

在snAAE患者中发现了14种细胞因子升高的独特特征.
像IL-6,IL-8,IL-10,VEGF-A和TNF-b这样的特定细胞因子被强调为潜在的snAAE生物标志物.
自体抗体查没有确定snAAE的特定点,但ASM响应性显示对脑等离子体膜蛋白的自体抗体增加.

结论:

细胞因子分析,而不是扩展的自身抗体查,为snAAE.提供了一个有前途的诊断方法.
通过细胞因子分析识别免疫失调,可以促进AAE患者的免疫治疗试验.
适应ASM的可能涉及独立于控制的免疫过活,这表明疾病进展可能独立于活动 (PISA).

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