不同类型和数量 代谢异常和成年人胆囊结石病的风险
Tingting Yang1, Jianqin Zhong1, Renhua Zhang1
1School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Frontiers in nutrition
|September 24, 2024
概括
代谢异常显著增加胆囊结石的风险,特别是在女性. 有三个或更多的代谢问题,如高血糖和高血压,与胆结石的发展有很强的相关性.
科学领域:
- 代谢健康和流行病学
- 胃肠病学和公共卫生
背景情况:
- 代谢异常与增加胆囊结石风险和并发症有关,造成严重的健康负担.
- 关于不同类型和数量的代谢异常与胆结石风险之间的具体关联的现有研究,特别是关于性别差异的研究,是有限的,往往是矛盾的.
研究的目的:
- 调查五种特定的代谢异常与胆结石风险之间的相关性.
- 探索代谢异常与胆结石风险之间的关联中潜在的性别特异性差异.
主要方法:
- 在中国多民族队列 (CMEC) 研究中利用了来自4075名中国成年人 (30-79岁) 的基线数据.
- 采用后勤回归模型来分析代谢异常 (失糖症,失脂症,高血压,中心肥胖症,血液尿酸异常) 和胆结石存在之间的关系,并进行性别分层分析.
主要成果:
- 总体胆结石检测率为7.0%,女性 (8.6%) 比男性 (4.1%) 高.
- 代谢异常的组合,特别是三个或更多的代谢异常,与胆结石风险有显著的关联. 例如,失糖症+高血压+中心肥胖导致赔率比 (OR) 为4.459.
- 性别分层分析显示,代谢异常与胆结石风险之间的关联在女性中更为明显.
结论:
- 该研究证实,各种类型和代谢异常的组合与胆结石的发展有关.
- 与男性相比,这些关联在女性中明显更强,突出显示了与代谢健康相关的胆结石风险的严重性别差异.
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