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病例报告:多个抗体阳性的严重肌痛性肌痛症与胸腺瘤相关的并发性肌痛炎

Chao Huang¹, Xuelian Dai¹, Jiacheng Liu²

¹Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang Cerebrovascular Disease (Stroke) Clinical Medical Research Center, Regional Medical Center for Neurological Diseases of Henan Province, Luoyang, China.

Frontiers in immunology

|September 24, 2024

概括

本病例报告详细介绍了一例罕见的同时发生的肌痛性肌痛症 (MG) 和异常性炎症性肌痛症 (IIM) 的病例,该病例发生在患有胸腺癌的患者身上. 诊断涉及广泛的测试,突出重叠的自身免疫神经肌肉疾病的复杂性.

科学领域:

神经学神经学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

骨髓灰质炎 (MG) 和异常性炎症性肌肉病 (IIM) 是不同的自身免疫疾病,分别影响神经系统和肌肉.
同时呈现的MG和IIM异常罕见,并且由于重叠的症状,如肌肉衰弱,造成诊断挑战.

研究的目的:

报告一个独特的案例,一名74岁的妇女被诊断出同时患有MG和IIM.
调查这种罕见的共发生的诊断过程和潜在的免疫病理机制,特别是在胸膜恶性瘤的背景下.

主要方法:

临床评估,包括评估肢体变动的软弱和肌肉疼痛.
诊断调查:重复频率电刺激,胸部CT,大腿MRI,血清抗体检测 (AChR,titin,RyR,anti-JO-1,Ro-52) 和淋巴结活检.
胸腺状细胞癌的组织病理学分析.

主要成果:

该患者被诊断出患有MG并发性IIM和胸腺状细胞癌.
对乙胆受体,蒂,瑞诺丁受体,抗JO-1和Ro-52抗体观察到阳性结果.
发现了与MG同时使用的IIM与胸腺瘤的关联.

结论:

同时的MG和IIM,特别是胸膜恶性瘤,代表了一个复杂的临床情景.
这种共发生的免疫病理机制可能与孤立的MG或IIM不同,需要进一步调查.
早期和全面的诊断评估对于识别罕见的重叠自身免疫神经肌肉疾病至关重要.

关键词:

乙胆受体抗体的抗体抗合成酶综合征是什么异形性炎症性肌肉病变 (Idiopathic Inflammatory Myopathy) 是一种异形性炎症性肌肉病变 (Idiopathic Inflammatory Myopathy) 的一种疾病.肌痛性骨髓灰质炎 (Myasthenia Gravis) 是一个严重的疾病.蒂莫莫马马 (thymomaoma) 是一种疾病.

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