传统草药奥里昂山治疗心力衰竭:系统性审查和元分析
Da Hae Jung1, Han-Gyul Lee2, Seungwon Kwon2
1Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Heliyon
|September 24, 2024
概括
奥里昂山 (ORS) 与传统西方医学 (CWM) 结合,显著改善了心力衰竭 (HF) 的结果,包括喷射分数和运动能力. 这种互补的方法为HF患者提供了安全有效的治疗选择,显示出超出单独CWM的前景.
科学领域:
- 心脏病学 心脏病学
- 综合医学是一个整体医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 心力衰竭 (HF) 带来了显著的死亡率和住院挑战,通常用带有电解质失衡风险的利尿剂进行管理.
- 在亚洲国家,Oryeongsan (ORS) 和其变体用于流体失衡管理,包括高频拥堵.
- 正在探索ORS作为一种补充疗法,以减轻HF治疗中的利尿制剂限制.
研究的目的:
- 审查结合Oryeongsan (ORS) 与常规西方医学 (CWM) 治疗心力衰竭 (HF) 的安全性和有效性.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2024年7月.
- 包含5069名参与者的59个随机对照试验 (RCT) 被纳入了元分析.
- 评估的结果包括左心室喷射率 (LVEF),总有效率 (TER),功能状态和不良事件.
主要成果:
- 与CWM单独相比,将CWM与ORS相结合显著改善了LVEF (平均差异6.36) 和TER.
- 在LVEDD,LVESD,6MWT,MLHF-Q,BNP,NT-proBNP,尿量,Lee的分数和NYHA类中观察到显著的改善.
- 治疗组和对照组之间在不良事件发生率上没有发现显著差异.
结论:
- 与CWM与ORS或其变体的组合在管理高频率方面表现出比单独使用CWM更高的有效性.
- 这种综合方法似乎是对HF的相对安全的治疗选择.
- 需要进一步的研究来验证这些发现.
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