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单细胞和亚细胞组件的SERS分析:一篇综述
M Barshutina1, A Arsenin2,1, V Volkov2,3
1Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Heliyon
|September 24, 2024
概括
表面增强拉曼光谱 (SERS) 为生物和医学分析提供了传统方法的可靠和方便的替代方案. 本综述涵盖了单细胞SERS的进展,挑战和未来前景.
科学领域:
- 分析化学 分析化学
- 生物技术是生物技术.
- 频谱学是一种光谱学.
背景情况:
- 表面增强拉曼光谱 (SERS) 是一种快速发展的非破坏性分析技术.
- 它的高灵敏度和特异性使其对生物和医学研究有价值,特别是对活细胞和亚细胞组件的分析.
- SERS正在成为一种常规和强大的工具,在可靠性和方便性方面超过了传统的分析方法.
研究的目的:
- 审查单细胞SERS的最新研究进展.
- 讨论单细胞SERS技术的挑战和未来前景.
- 为了分类和分析不同的SERS平台.
主要方法:
- 将SERS平台分为基于合体,基板或混合型的类别.
- 基于联结体依赖的分类:以联结体为基础或无联结体.
- 按检测方法分组:基于标签或没有标签.
- 详细讨论每个SERS平台类型的优点,缺点和应用.
主要成果:
- SERS平台可以根据其物理性质 (合体,基质,混合体),连接体使用 (基于连接体/免费) 和检测策略 (基于标签/免费) 进行有效分类.
- 每种SERS平台类型都有不同的优点和缺点,影响其适用于特定应用的适用性.
- 该审查强调了SERS在生物和医学研究中的日益增长的实用性和多样化的应用.
结论:
- 单细胞SERS是一种强大的技术,在生物和医学领域具有重大潜力.
- 了解不同的SERS平台类型对于优化实验设计和应用至关重要.
- 预计持续的研发将克服当前的挑战,并扩大SERS应用的范围.
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