流感和肠道微生物群:一种隐藏的治疗联系
Cheng Luo1, Yi Yang2, Cheng Jiang2
1Chengdu University of Traditional Chinese Medicine, Chengdu, 610032, China.
Heliyon
|September 24, 2024
概括
肠道微生物群影响流感. 通过便微生物种移植 (FMT) 和益生菌等干预措施调节肠道细菌及其代谢物,可以通过减少炎症和病毒载荷来改善流感的结果.
科学领域:
- 微生物组研究的研究.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在宿主生理学中起着至关重要的作用,并且越来越多地被认为是流感病原发生的一个因素.
- 肠道细菌及其代谢物的变化与流感有关,这表明疾病的"肠道特征".
- 了解这种联系为针对流感的新型治疗策略提供了潜力.
研究的目的:
- 审查健康个体和流感患者之间的肠道微生物群的差异.
- 探索肠道微生物群代谢物和流感之间的关系.
- 通过肠道微生物群调节讨论流感预防和治疗的策略.
主要方法:
- 在PubMed和Web of Science数据库中进行文献搜索,截至2023年12月.
- 关键词包括"流感"",肠道微生物群"",中国传统医学"",代谢物"",益生菌"",益生菌"和"机器学习".
- 专注于研究肠道微生物群调节和流感治疗之间的治疗联系.
主要成果:
- 便微生物群移植 (FMT),微生物制剂 (益生菌,益生菌) 和传统中医药有效调节肠道微生物群,改善流感的结果.
- 干预措施促进有益的细菌 (例如,Bacteroidetes,Bifidobacterium) 和减少有害的细菌 (例如,蛋白质细菌).
- 调节短链脂肪酸 (SCFA),氨基酸 (AAs),胆汁酸和单胺等代谢物,缓解肺炎并产生抗流感作用.
结论:
- 肠道微生物群及其代谢物为流感提供直接或间接的治疗益处,具有显著的研究潜力.
- 这些发现为临床预防和治疗策略提供了参考.
- 未来的研究应该确定关键的微生物菌株,特定的代谢物和针对流感和其他呼吸道病毒感染的向干预的免疫机制.
相关概念视频
Bacterial Flora of the Large Intestine
397
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
397
Irritable Bowel Syndrome I: Introduction
255
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
255
Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
Anatomy of the Intestines
71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K


