以生理学为灵感的双焦前侧-双侧tACS用于增强工作记忆
Monika Pupíková1, Pablo Maceira-Elvira2,3, Sylvain Harquel2
1Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Heliyon
|September 24, 2024
概括
以生理学为灵感的横交替电流刺激 (tACS) 在老年人中适度改善了工作记忆 (WM). 针对前侧-双侧网络的双焦tACS增强了处理速度,表明潜在的认知增强.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 老年学是一门学科.
背景情况:
- 老龄化人口经历了显著的工作记忆 (WM) 的下降.
- 跨交替电流刺激 (tACS) 显示了对认知增强的潜力.
- 以生理学为灵感的tACS可以优化大脑网络调制以获得认知效益.
研究的目的:
- 调查个性化,灵感来自生理学的多焦点tACS对健康老年人WM表现的影响.
- 探索使用tACS用于认知增强的前端-双层网络的调制.
- 为了检查单焦/双焦的theta-tACS和交叉频率的theta-gamma相互作用.
主要方法:
- 两个盲目的交叉实验,使用个性化,在前额-双肩网络上以生理学为灵感的tACS.
- 在各种tACS条件下 (单焦,双焦,交叉频率) 管理的在线工作记忆任务.
- 使用静止状态功能磁共振成像 (rs-fMRI) 和电脑成像 (EEG) 评估网络连接.
主要成果:
- 与假装相比,前额单聚焦的theta tACS显示WM准确度 (d = 0.30) 略有改善.
- 面对对面的tACS,特别是双焦相中的theta tACS,显著提高了WM处理速度 (d = 0.41).
- 交叉频率刺激提供了适度的处理速度提升,对准确度有不同的影响.
结论:
- 个性化,生理学启发的tACS,特别是前额-双肩网络的双焦色甲基刺激,可以提高老年人的认知处理速度.
- 这项研究有助于理解针对性脑刺激在衰老过程中用于认知增强的应用.
- 对特定的tACS协议的进一步研究可以优化WM性能并减轻与年龄相关的认知衰退.
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