在健康的白色脂肪组织和肥胖中的NADPH氧化酶:功能,调节和临床影响
François R Jornayvaz1,2,3, Karim Gariani1,3, Emmanuel Somm1,2,3
1Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Department of Internal Medicine, Geneva University Hospitals and University of Geneva Medical School, Geneva, Switzerland.
Obesity (Silver Spring, Md.)
|September 24, 2024
概括
活性氧物种调节白色脂肪组织 (WAT) 功能. 通过NADPH氧化酶 (NOXs) 的失调生产有助于肥胖和2型糖尿病,需要进一步研究向疗法.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 活性氧物种 (ROS) 调节白色脂肪组织 (WAT) 扩张和新陈代谢.
- 无法控制的ROS产生与病态的WAT扩张,胰岛素耐药性和2型糖尿病有关.
- NADPH氧化酶 (NOXs) 是WAT细胞中ROS的关键生产者.
研究的目的:
- 审查NOX异构体在健康WAT中的生理作用.
- 要总结改变NOX衍生氧化剂生产的代谢后果.
- 突出NOX在脂肪和代谢平衡中的作用.
主要方法:
- 使用NOX缺乏的小鼠模型进行的临床前研究的审查.
- 对NOX抑制剂的临床研究的分析.
- 对NOX突变和代谢障碍的人类遗传数据的检查.
主要成果:
- 从NOX衍生的氧化剂在WAT中起着双重作用,与代谢功能障碍相关的失调.
- 临床前模型显示NOX缺乏小鼠的WAT变化.
- 临床数据表明NOX与人类代谢疾病有关.
结论:
- 了解WAT氧化还原网络中的NOX功能至关重要.
- 向NOX衍生的氧化剂可能为肥胖和相关的代谢病理提供治疗策略.
- 进一步的研究对于开发精密的氧化还原基疗法至关重要.
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