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Updated: Jun 12, 2025

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CD8α结构域增强GUCY2C CAR-T细胞的有效性

Trevor R Baybutt1, Ariana A Entezari1, Adi Caspi1

  • 1Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Cancer biology & therapy
|September 24, 2024
PubMed
概括

CD8ɑ链和跨膜域增强了CAR-T细胞对GUCY2C的亲和力,改善了对结直肠癌的抗瘤疗效,特别是在低抗原瘤中.

关键词:
在CAR-T细胞疗法中.化学抗原受体的化学抗原受体这就是GUCY2C.结肠直肠癌是什么意思

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