老年人中功能,性别和痴呆风险:基于人口的队列研究
Dae Jong Oh1, Ji Won Han2,3, Jun Sung Kim2
1Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of Korean medical science
|September 24, 2024
概括
老年男性经常与痴呆症风险增加和认知能力下降有关. 这突出了对老年男性认知健康监测的潜在指标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 功能障碍可能是大脑功能障碍的信号,但其与痴呆症风险的联系尚不清楚.
- 研究功能与认知衰退和痴呆症的关联对于了解神经退行性疾病风险因素至关重要.
研究的目的:
- 研究老年人口功能与认知衰退和痴呆症风险之间的关系.
- 根据习惯,识别潜在的痴呆风险早期指标.
主要方法:
- 对5064名年龄≥60岁的韩国人进行前性队列研究,随访8年.
- 通过临床面试评估每口的周期;监测认知表现和痴呆症诊断 (所有原因和阿尔茨海默病).
- 包括从体积分析的子集中的脑MRI.
主要成果:
- 与<10个周期/咬咬的男性相比,≥30个周期/咬咬的男性表现出更快的认知衰退和更高的痴呆和阿尔茨海默病 (AD) 风险.
- 男性的周期增加与认知控制区域的大脑体积减少相关.
- 在女性中没有发现任何显著的关联.
结论:
- 老年男性经常与痴呆症风险增加和认知能力下降有关.
- 经常的老年男性代表了一个需要仔细认知评估和监测的人群.
- 功能可能成为老年男性认知健康的潜在生物标志物.
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