相关实验视频

Updated: Jun 23, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

利用编程细胞死亡模式来预测OSCC的预后和治疗敏感性

An Wang^1,2, Chi Zhang^1,2, Yuhan Wang^1,2

¹Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

|September 24, 2024

概括

一个新的细胞死亡指数 (CDI) 生物标志物预测了口腔状细胞癌 (OSCC) 的结果. 该指数有助于预后和治疗预测,提供有关癌症细胞分化的见解.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

编程细胞死亡 (PCD) 在癌症的发展和治疗反应中起着关键作用.
了解这些复杂的关联对于改善口腔状细胞癌 (OSCC) 患者的治疗结果至关重要.

研究的目的:

通过整合多种编程细胞死亡模式来开发OSCC的新型预后和预测生物标志物.
建立细胞死亡指数 (CDI) 来评估患者的预后,并预测OSCC的治疗反应.

主要方法:

在12个PCD模式上使用单变Cox回归,Kaplan-Meier存活率和LASSO分析构建了CDI.
通过多变量考克斯回归,开发了一种将CDI与临床病理参数结合在一起的名图.
使用scRNA-seq数据分析了CDI,免疫格局和治疗敏感性之间的关联.

主要成果:

一个包括10个选定的PCD基因的预后签名是OSCC的衍生.
在独立的患者队列中,CDI和nomogram表现出强大而优异的预后性能.
CDI显示与瘤透免疫细胞和免疫治疗结果的负相关性,其中关键基因参与细胞分化.

结论:

细胞死亡指数 (CDI) 已被确立为OSCC预后和治疗反应的强大预测指标.
这项研究表明CDI在癌细胞分化过程中的潜在作用.
在OSCC治疗中,CDI为个性化医疗方法提供了一个新的工具.

关键词:

化疗对化疗反应的反应免疫系统的景观.免疫疗法反应的免疫疗法反应口腔状细胞癌的癌症.被编程的细胞死亡.

更多相关视频

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

Author Spotlight: Developing Multiplexed Kinetic Assays for Organoid-Based Drug Response Analysis

Author Spotlight: Developing Multiplexed Kinetic Assays for Organoid-Based Drug Response Analysis

Published on: January 5, 2024

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...