更年期荷尔蒙疗法和骨关节炎风险:韩国以人口为基础的回顾性研究
Jin Li Lee1, Jiwon Seo1, Yeonjin Shin1
1Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Journal of menopausal medicine
|September 24, 2024
概括
更年期荷尔蒙疗法 (MHT) 的使用与较高的骨关节炎风险有关,特别是在除部以外的关节. 这种关联在不同类型的MHT中观察到,包括tibolone,雌激素-孕激素治疗和雌激素治疗.
科学领域:
- 生殖医学 生殖医学
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
背景情况:
- 更年期激素治疗 (MHT) 被广泛用于管理更年期症状.
- MHT对关节健康,特别是骨关节炎的潜在影响需要彻底调查.
研究的目的:
- 评估更年期激素治疗 (MHT) 与患关节骨炎的风险之间的关联.
- 检查特定的MHT配方及其对骨关节炎的差异性风险.
主要方法:
- 一项基于人口的回顾性队列研究,利用2007-2020年韩国医疗保险索赔数据.
- 确定40岁以上的绝经后女性开始MHT (n=26,354) 并将它们与非MHT用户以1:1的比例匹配,使用倾向分数匹配.
- 使用Cox比例危险模型分析了骨关节炎风险,随访时间中位数为8.2年.
主要成果:
- 更年期激素治疗 (MHT) 与整体骨关节炎的风险增加有关 (HR, 1.154; 95% CI, 1.117-1.193).
- 膝关节 (HR, 1.148) 和其他关节炎 (HR, 1.205) 的风险增加,但对关节炎的风险没有统计学意义.
- 蒂博隆 (HR, 1.211),雌激素-孕激素治疗 (EPT) (HR, 1.092) 和雌激素治疗 (ET) (HR, 1.235) 都显示与非MHT相比,骨关节炎风险增加.
结论:
- 更年期激素治疗 (MHT) 与患关节炎的风险更高有关.
- 增加的风险在tibolone,EPT和ET之间是一致的,对非关节有显著的影响.
- 还建议增加关节骨关节炎风险的趋势,需要进一步调查.
更多相关视频
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.1K
07:20Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
452
相关概念视频
01:28Menopause
145
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
145
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K