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为患有1型糖尿病和A1c升高的年轻人提供自动化胰岛素
Alisa Boucsein1, Yongwen Zhou1,2, Venus Michaels1
1Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.
NEJM evidence
|September 24, 2024
概括
自动注射胰岛素可显著降低1型糖尿病儿童和青少年的糖化血红蛋白. 这种先进的治疗改善了葡萄糖的控制,但没有增加严重的低血糖或糖尿病酸性的风险.
科学领域:
- 内分泌学 在内分泌学.
- 儿童糖尿病管理管理
- 医疗技术 医疗技术 医学技术
背景情况:
- 自动注射胰岛素 (AID) 是1型糖尿病 (T1D) 的成年人的标准.
- 在患有高血糖血红蛋白的儿科患者群体中,AID的有效性和安全性数据有限.
- 这项研究解决了儿童和青少年患有T1D和血糖控制不良的证据的需求.
研究的目的:
- 评估自动化胰岛素输送系统在患有1型糖尿病和高糖血红蛋白的儿童和青少年中的疗效和安全性.
- 在这个人群中,将自动胰岛素输送与传统糖尿病护理进行比较.
主要方法:
- 进行了一项多中心,开放标签,随机对照试验.
- 80名患有1型糖尿病和糖化血红蛋白≥8.5%的参与者 (7-25岁) 被随机分配1:1到AID (MiniMed 780G) 或通常的护理.
- 主要结局是13周糖化血红蛋白的变化.
主要成果:
- 与通常治疗相比,自动注射胰岛素显著降低了 -2.5个百分点的糖化血红蛋白 (P<0.001).
- 使用AID的参与者每天平均花费8.4小时在目标葡萄糖范围内.
- 在AID组中没有发生严重的低血糖或糖尿病酸事件,而对照组经历了这样的事件.
结论:
- 自动注射胰岛素有效降低1型糖尿病和高血糖水平的儿童和青少年的糖化血红蛋白.
- 在这个队列中,MiniMed 780G系统表现出了有利的安全概况.
- 与通常的糖尿病护理相比,AID对患有无控1型糖尿病的儿科患者来说是一个显著的进步.
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