雷姆睡眠仍然具有悖论性:子状态由乳头皮层和皮层皮层功能连接性决定
Hélène Bastuji1,2, Maëva Daoud1, Michel Magnin1
1Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center, INSERM U1028; CNRS, UMR5292, Université Claude Bernard, Bron, France.
The Journal of physiology
|September 24, 2024
概括
在悖论性睡眠 (REM睡眠) 期间,lamus中的缓慢的三角波会破坏大脑的连接. 丘陵体和皮质之间的这种断开,以及皮质区域之间的断开,会影响梦境体验.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 认知神经科学 认知神经科学
背景情况:
- 悖论性睡眠 (PS,REM睡眠) 具有与清醒相似的皮质活动.
- 后关联性 thalamus 在 PS 期间显示缓慢的三角波,从而产生 thalamo-cortical 频率解离.
- 这种分离对大脑连接的功能影响尚未完全理解.
研究的目的:
- 为了研究在悖论性睡眠期间的乳头皮层频率解离的功能后果.
- 为了检查不同PS状态期间的后丘脑和皮质网络之间的功能连接的变化.
- 探索后关联性 thalamus 在跨thalamic 通信中的作用.
主要方法:
- 在21名患者中进行了内和皮层内记录.
- 连贯性分析,以评估后丘脑 (中脉脉) 和皮层网络之间的功能连接.
- 在慢波体活动 (delta PS) 与快速PS和清醒期间的连接性比较.
主要成果:
- 慢波体活动 ("delta PS") 比快速PS更为普遍.
- 与快速PS和清醒相比,在deltaPS期间,thalamo-cortical和皮层-皮层的功能连接性显著下降.
- 德尔塔/快速体交替与经典的强力/相位PS状态不一致.
结论:
- 后关联性 thalamus,特别是中间脉动,对于皮层区域之间的跨thalamic 通信至关重要.
- 在三角形PS过程中中断这种通信,就会损害皮质区域之间的功能结合.
- 这种受损的结合可能有助于改变梦境中的感知体验.
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