中枢神经系统沙丘病症:一个国家基的注册研究
Yazan Al-Zamer1, Sami Al-Horani1, Marah Akhdar1
1Jordan University of Science and Technology.
概括
中枢神经系统 (中枢神经系统) 类麻疹影响超过11%的患者,主要是女性和白人. 这种情况往往导致多器官参与,慢性疼痛和残疾,需要皮质类固醇治疗.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 中枢神经系统 (CNS) 型硬化症是一种罕见的疾病,关于其人口统计,诊断和治疗的数据有限.
- 现有的关于中枢神经系统沙尔科病的文献很少,并且往往不一致,这凸显了对综合性研究的需要.
研究的目的:
- 调查美国中枢神经系统类病的人口统计,诊断方法,管理策略和临床并发症.
- 通过全国性的注册表,提供对中枢神经系统沙尔科毒症患者特征的见解.
主要方法:
- 在2014年6月至2019年8月期间,对3835名受访者进行了回顾性分析,这些受访者参加了Sarcoidosis Research Foundation Sarcoidosis Advanced Registry for Cures问卷 (FSR-SARC).
- 倾向性得分匹配,摘要,单变量和多变量分析被用于比较患有和没有中枢神经系统肉类病变的患者.
主要成果:
- 11.55%的患者 (420/3634) 患有中枢神经系统肉类发病症,女性 (70.5%) 和白人 (73.1%) 的患病率更高.
- 诊断时的平均年龄为43.3岁,75.7%的人经历了多器官参与 (≥3个器官).
- 头骨MRI是最常见的诊断工具 (76.5%异常),皮质类固醇是主要治疗方法 (49.0%),其次是细胞毒剂 (42.9%).
结论:
- 在这个队列中,中枢神经系统肉类症的患病率与以前的发现一致.
- 头骨MRI是最常用于诊断中枢神经系统类菌病的成像方式.
- 皮质类固醇是主要的治疗方法,中枢神经系统的类固醇症与慢性疼痛和残疾等重大并发症有关.
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