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Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.

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相关实验视频

Updated: May 5, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

使用多传感器生理模型监测手术性 nociception.

Sandya Subramanian¹, Bryan Tseng², Marcela Del Carmen³

¹Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America

|September 24, 2024

概括

客观地监测手术性感觉 (神经系统对有害刺激的反应) 对于麻醉至关重要. 这项研究引入了使用自主神经系统活动的新模型,以准确地跟踪手术期间的感觉,改善患者的护理.

关键词:

麻醉是一种麻醉.自主神经系统自主神经系统这是一个多式联络模式.过程中的点点过程.外科手术的感觉错觉.

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Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

相关实验视频

Last Updated: May 5, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

科学领域:

麻醉学麻醉学
神经科学是一个神经科学.
生物医学工程生物医学工程

背景情况:

目前用于监测外科手术感觉的方法依赖于对心率和血压的主观评估.
对 nociception 的客观监测是具有挑战性的,导致潜在的手术内药物过量或过量服用.
无效的感觉管理会导致复杂的术后疼痛和认知功能障碍,特别是在老年患者中.

研究的目的:

开发和验证客观的,基于多传感器的标记物,用于定量化手术性感觉.
通过提供准确的,实时的感觉监测来改善手术内麻醉护理.
建立直接从手术数据中获得的基于生理学的标记.

主要方法:

收集了101次手术的综合数据集,包括感觉刺激和药物.
使用心脏动作潜力和汗腺活动的点过程模型,开发了自主神经系统活动的指数.
构建可解释的监督和无监督模型来量化外科手术的感觉.

主要成果:

开发的模型准确地跟踪在手术期间的感知刺激.
模型对 nociception 的描述与已知的生理对疼痛反应一致.
与现有的恶感感知监测器相比,新的标记物显示出更高的准确性.

结论:

这项工作向客观的,基于生理学的外科性 nociception 标记提供了显著的进步.
开发的标记物来自实际的手术数据,避免依赖代用实验模型.
这些客观标志物有可能优化麻醉护理并改善患者的治疗结果.