在子宫内膜癌中EIF4A3/CDC20轴的瘤作用
Yan Lin1, Lili Kong1, Yiting Zhao1
1Department of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, 315211, China.
Journal of molecular medicine (Berlin, Germany)
|September 24, 2024
概括
细胞启动因子4A-3 (EIF4A3) 在子宫内膜癌 (EC) 中升高,通过稳定细胞分裂循环20 (CDC20) mRNA,促进瘤生长和转移. 作为CDC20抑制剂的Apcin为EC提供了一个潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 细胞启动因子4A-3 (EIF4A3) 对于RNA处理和细胞调节至关重要.
- 它在子宫内膜癌 (EC) 中的作用尚未完全阐明.
- 了解EIF4A3在EC中的功能对于开发向疗法至关重要.
研究的目的:
- 研究EIF4A3在子宫内膜癌中的表达和功能.
- 阐明EIF4A3影响EC进展的分子机制.
- 为了确定EC治疗的潜在治疗点.
主要方法:
- 对EC样本进行生物信息学分析.
- 免疫组织化学评估EIF4A3表达.
- 细胞增殖,迁移和入侵测定.
- mRNA稳定性测试和淘汰实验.
- 用Apcin治疗,这是一个CDC20抑制剂.
主要成果:
- 与正常组织相比,EC组织中的EIF4A3表达显著上调.
- 高EIF4A3表达促进了EC细胞的增殖,迁移和入侵.
- EIF4A3稳定细胞分裂环素20 (CDC20) mRNA,导致其上调.
- 击败CDC20或治疗Apcin可以对抗EIF4A3诱导的促癌效应.
结论:
- EIF4A3在子宫内膜癌瘤发生和转移中发挥着重要作用.
- EIF4A3-CDC20轴是推动欧洲共同体发展的关键机制.
- 用像Apcin这样的药物准EIF4A3或其下游效应器CDC20为EC提供了一个有前途的治疗策略.
相关概念视频
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K