神经瘤学研究中的种族:我们如何做,我们如何做得更好?
Asfand Baig Mirza1,2, Feras Fayez3, Sami Rashed4
1Department of Neurosurgery, Kings College Hospital, Denmark Hill, London, SE5 9RS, UK. asfand.mirza@nhs.net.
Journal of neuro-oncology
|September 24, 2024
概括
少数民族在神经瘤学临床试验中代表性不足,关于种族如何影响结果的数据有限. 改善多样性和报告对于个性化癌症护理至关重要.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 健康差异 在健康上的差异
背景情况:
- 在神经瘤学临床试验中少数民族的代表性不太清楚.
- 现有的数据不充分描述了种族对治疗结果的影响.
研究的目的:
- 在神经瘤学III期和IV期试验中系统地审查和元分析少数民族的代表性.
- 探索种族对患者结果的影响.
- 确定在试验出版物中包含种族数据的预测因素.
主要方法:
- 系统的文献审查和元分析,遵循PRISMA指南.
- 搜索了多个数据库,搜索了涉及成人和/或儿科患者的第三期和第四期神经瘤学试验.
- 综合了关于整体存活率,无事件存活率和跨种族不良结果的数据.
主要成果:
- 审查的试验中的大多数参与者被确定为白人,这表明少数群体的代表性显著不足.
- 分析发现,根据种族,结果没有显著差异,这可能是由于数据报告有限且不充分.
- 包括种族数据的预测因素包括北美的试验,药物/生物制剂以及慈善机构或制药公司的资金.
结论:
- 少数群体在神经瘤学试验中的显著代表性不足需要更具包容性的招聘策略.
- 对种族对结果影响的不充分描述强调了需要改进报告标准的必要性.
- 未来的研究必须优先了解种族的作用,以实现个性化的神经瘤治疗方法.
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