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BLEscope:一个蓝牙低能 (BLE) 显微镜用于无线多对比功能成像
IEEE transactions on bio-medical engineering
|September 24, 2024
概括
研究人员开发了BLEscope,一种使用低功耗芯片上的系统的无线显微镜,用于先进的神经成像. 这项创新使得小动物的无,低功耗功能成像成为可能,从而推进临床前和临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 神经成像技术的神经成像技术
- 无线传感器系统无线传感器系统
背景情况:
- 低功耗无线系统 (SoC) 的进步推动了物联网应用.
- 对小型动物的轻量级,不受束,低功率的神经成像系统的需求日益增长.
研究的目的:
- 探索使用低功耗资产监控系统进行无线功能成像.
- 开发一种用于光和血液动力学对比成像的新型架构.
- 创建一个无线显微镜用于体内应用.
主要方法:
- 集成了一个蓝牙低能耗 (BLE) 5.2 SoC与CMOS图像传感器.
- 开发了一种多对比光学前端 (光和内在光学信号通道).
- 建立了一个BLE协议,用于远程操作和以1 fps的速度在体内采集图像.
主要成果:
- 创建了一个无线显微镜"BLEscope".
- 在100mAh电池上实现了~1.5小时的连续无线成像的基准.
- 在体内成功成像光标记物,脑瘤细胞和血管反应.
结论:
- BLEscope 证明了低功耗无线功能成像的可行性.
- 微型化版本可能会导致植入式或无线显微镜.
- 有潜力改变临床前和临床神经成像.
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