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3D打印的即时释放固体剂型:US11622940B2的专利评估

Akshay Sharma¹, Ritu Rathi¹, Sanchay Sharma¹

¹Chitkara College of Pharmacy, Chitkara University, Punjab, India.

Pharmaceutical patent analyst

|September 24, 2024

概括

三维 (3D) 打印提供了灵活的平板电脑制备. 这项研究优化了具有独特通道的3D打印化胺片,显著改善了药物的溶解和分解,以便立即释放.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

三维 (3D) 打印为制药剂型提供了先进的制造能力.
控制药物释放概况对于治疗疗效至关重要.
优化即时释放配方可以提高药物的生物可用性.

研究的目的:

描述立即释放的3D打印的化物胺片的制备过程.
为了研究结合通道 (片) 对平板电脑性能的影响.
为了增强化西胺片的分解和溶解概况.

主要方法:

使用热挤出制备的含有药物的丝制剂.
化沉积建模 (FDM) 用于3D打印各种形状和尺寸的平板电脑.
在平板电脑结构中整合内部通道 (片).
扫描电子显微镜 (SEM) 用于形态分析.

主要成果:

通过使用FDM成功制造3D打印的化胺片.
由于插入间隙,在分解和溶解配置中得到了明显的改善.
SEM证实了印制平板电脑中缺口的存在和结构完整性.

结论:

3D打印是一种可行的技术,用于生产具有增强药物释放特性的即时释放片.
在3D打印的平板电脑中整合隙显著改善了甲的分解和溶解.
这种方法为优化口服剂型性能提供了一种新的策略.

关键词:

通过3D打印打印3D打印.在FDM的FDM.在HME中,HME是HME.药物输送系统是药物输送系统.化纤维制造 (FFF) 是一种酸盐亚化物药片药片药片药片药片药片

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