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硫化酸[4]烯:一种通用且有效的口味掩饰剂
Meng-Meng Chen1, Shujie Lin2, Ze-Han Wang1
1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China.
ACS applied materials & interfaces
|September 24, 2024
概括
硫化酸[4] (SAC4A) 是一种新型的超分子剂,可以有效地掩盖16种不同药物的苦味. 这种普遍的口味掩饰方法提高了药物配方和患者的遵守性.
科学领域:
- 制药科学 制药科学
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
背景情况:
- 许多活性药物成分 (API) 具有苦味,对患者的遵守和治疗结果产生负面影响.
- 有效的口味掩饰策略对于开发可口味的口服药物配方至关重要.
- 开发能够处理各种苦药分子的通用掩饰剂仍然是制药研究中的一个重大挑战.
研究的目的:
- 引入和评估硫化酸[4] (SAC4A) 作为一种普遍的超分子口味掩饰剂,用于苦药.
- 调查SAC4A在一系列苦药药物化合物中的结合亲和力和口味掩盖功效.
- 评估SAC4A在潜在的口服药物输送应用中的生物相容性.
主要方法:
- 硫酸酸[4] (SAC4A) 的合成和表征.
- 有约束力的研究评估SAC4A对16种不同的苦药分子的亲和力,包括类化合物,黄类化合物和类化合物.
- 评估SAC4A在掩盖这些药物的苦味方面的口味掩盖效果.
- 对SAC4A的生物相容性评估.
主要成果:
- SAC4A 显示出一个深层腔结构,促进了强烈的疏水性相互作用,并为苦药分子提供了很大的结合面积.
- 在SAC4A和16种不同的苦药化合物之间观察到高结合亲缘关系.
- 试验药物的苦味在与SAC4A.复合时被有效地掩盖.
- SAC4A表现出良好的生物相容性,表明其适合于制药应用.
结论:
- 硫酸酸[4] (SAC4A) 作为一种高效和通用的超分子口味掩饰剂.
- SAC4A独特的结构特征使其能够在各种药物类别中强强地结合并有效地掩盖苦味.
- SAC4A为改善苦味口服药物的可口性提供了一个有希望的解决方案,从而提高了患者的服药性和治疗疗效.
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