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针对牛奶过敏使用低过敏性蛋白质多配方:一个概念证明
M Victoria Gil1, Gloria Gutiérrez-Díaz2, Nieves Higuero1
1IACYS-Green Chemistry and Sustainable Development Unit, Department of Organic and Inorganic Chemistry, Faculty of Sciences, University of Extremadura, 06006 Badajoz, Spain.
Food chemistry
|September 24, 2024
概括
皮中的多在减少对牛奶蛋白质 (如β-乳糖球蛋白和素) 的过敏反应方面表现有前途. 这项研究表明,一种潜在的新口服治疗食物过敏,利用食物浪费.
科学领域:
- 食品化学 食品化学
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
背景情况:
- 牛奶过敏 (CMA) 是一个日益严重的健康问题,由对牛奶蛋白质过敏引起.
- 目前对CMA的治疗方法通常涉及严格的避免,突出显示了对新治疗策略的需求.
- 修改牛奶蛋白质结构可能会诱导低过敏反应.
研究的目的:
- 为了研究从皮多中提取的可食用矩阵的潜力,作为牛奶过敏的治疗方法.
- 评估这些多醇修饰矩阵对乳蛋白过敏患者IgE结合的影响.
- 探索在循环经济框架内对植物废弃物的价值化,用于食品化学应用.
主要方法:
- 创建可食用矩阵,其中包含从皮中提取的多.
- 测试这些矩阵在降低来自β-乳糖球蛋白和素过敏血清的IgE结合中的有效性.
- 牛奶蛋白因多相互作用而引起的结构变化的分析.
- 评估治疗反应的个体间变异性.
主要成果:
- 聚烯化合物显著降低了对β-乳糖球蛋白过敏的患者血清中的IgE结合.
- 对素过敏血清观察到IgE结合的类似减少.
- 聚醇诱导了牛奶蛋白的显著结构变化,尽管具有个体间的变化.
- 这项研究表明,开发多丰富的口服治疗食物过敏的有希望的方法.
结论:
- 皮多显示出降低牛奶蛋白质过敏性的潜力.
- 富含多的方法为口服治疗食物过敏提供了一个有前途的途径.
- 这项研究通过将蔬菜废物升级为有价值的食品化学应用来支持循环经济.
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