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Updated: Jun 12, 2025

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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生殖系遗传变异导致骨髓扩散性瘤和遗传性骨髓扩散性表型的发生

Jonathan Lim1, David M Ross2, Anna L Brown3

  • 1Department of Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital, Adelaide, Australia; Haematology Directorate, SA Pathology, Adelaide, Australia.

Leukemia research
|September 24, 2024
PubMed
概括

患有骨髓性恶性瘤的家族倾向与多个基因中的生殖系变异有关. 了解这些遗传因素可以改善诊断,风险咨询和骨髓增殖性瘤 (MPN) 的临床决策.

关键词:
家庭聚类是家庭的聚类.生殖系变体的生殖系变体遗传性倾向 遗传性倾向 遗传性倾向类似于MPN的疾病骨髓增殖性瘤是一种多发性瘤.多态形态的多态化

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