在Kiss1r淘汰赛小鼠中减少了自发的轮子运行行为
Raj Patel1, Aaron Gomes1, Shane K Maloney1
1School of Human Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Perth, Australia.
Physiology & behavior
|September 24, 2024
概括
基斯佩普丁信号调节雄性小鼠的昼夜活动. 基斯佩丁受体淘汰赛小鼠表现出跑步减少,但通过自愿运动可以预防肥胖.
科学领域:
- 神经内分泌学神经内分泌学
- 循环节生物学 循环节生物学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 基斯丁及其受体 (Kiss1r) 涉及能量平衡,温度调节和昼夜节律.
- 基斯1r淘汰赛 (KO) 小鼠表现出低体和肥胖症,为研究基斯佩普丁更广泛的功能提供了一个模型.
研究的目的:
- 用Kiss1r KO小鼠研究kispeptin信号在昼夜运动行为中的作用.
- 评估淋巴切除术 (GDX) 对活动水平和身体质量的影响,与kisspeptin信号传递相关.
主要方法:
- 测量了完整和淋巴切除的Kiss1r KO和野生类型 (WT) 小鼠的自愿轮子运行活动.
- 分析了身体质量,组织组织学 (WAT,BAT,肌肉) 和神经元标记物表达 (素,多巴胺,Iba1).
主要成果:
- 与WT对照组相比,Kiss1r KO小鼠的跑步距离显著减少,特别是在雄性中.
- 淋巴切除术影响了WT小鼠的跑步活动,男性GDX Kiss1r KO的减少不那么明显.
- 在参与志愿活动的GDX Kiss1r KO小鼠中没有观察到肥胖,尽管有遗传背景.
- 在雄性Kiss1r KO小鼠的弧形核中观察到微质激活的增加 (Iba1).
结论:
- 基斯佩丁信号传递对于雄性小鼠的正常昼夜运动活动至关重要.
- 自愿的体力活动可以减轻Kiss1r KO小鼠肥胖的发展,这表明能量消耗和kisspeptin通路之间的复杂相互作用.
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