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新生儿的pemphigus vulgaris是一种常见的

Sanmitra Aiholli¹, Arun Inamadar², Ajit B Janagond³

¹Dermatology, BLDE Deemed to be University, Vijayapura, Karnataka, India.

BMJ case reports

|September 24, 2024

概括

新生儿原体 (PV) 发生在一个患有PV的母亲将抗体传给她的婴儿时. 母亲和婴儿都康复了,婴儿自发地愈合,母亲对rituximab治疗做出了反应.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
新生儿科学新生儿科学

背景情况:

黄 (Pemphigus vulgaris,简称PV) 是一种自身免疫性水泡性疾病.
母亲的抗体可以转移到胎儿,可能导致新生儿自身免疫性疾病.
新生儿黄是一种罕见的疾病,表现为皮肤病变.

研究的目的:

报告一个新生儿pemphigus vulgaris的病例.
突出这一罕见疾病的诊断方法和临床过程.
讨论管理和治疗结果.

主要方法:

新生儿的临床表现有水泡和侵蚀.
皮肤活检与组织病理学和直接免疫光学用于母亲诊断.
间接免疫光检测对母亲和新生儿的血清抗体对desmogleins 1和3的测定.

主要成果:

组织病理学和直接免疫光检测证实了母体的pemphigus vulgaris.
在母亲和新生儿中,对desmogleins 1和3的阳性血清抗体证实了新生儿PV.
新生儿的病变在两周内自发消失.
母亲在经过两个月的修复药治疗后实现了缓解.

结论:

新生儿皮 (pemphigus vulgaris) 是一种移植性自身免疫性疾病.
诊断确认依赖于针对抗德斯莫格林抗体的血清学检测.
这种情况通常在新生儿中具有良性和自我限制的过程,而母亲的治疗是至关重要的.

关键词:

皮肤病学皮肤病学产科,妇科和生育学以及生育学.儿科 (药物和药物)

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