在随机临床试验中对再生移植材料的使用进行系统审查和元分析,以保护插槽
Seyed Abdolhojeh Alavi1, Mahsa Imanian2, Salem Alkaabi3
1Department of Oral and Maxillofacial Surgery/Oral Pathology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Oral surgery, oral medicine, oral pathology and oral radiology
|September 24, 2024
概括
再生材料有助于在拔牙后保护骨. 重组的人类BMP-2 (rhBMP-2) 在宽度保存方面表现出色,而L-血小板丰富的纤维素 (L-PRF) 则提供了具有成本效益的替代方案.
科学领域:
- 牙科再生医学 牙科再生医学
- 在口腔外科手术中.
- 骨再生 骨的再生
背景情况:
- 拔牙后膜骨的再吸收是一个重要的临床问题.
- 研究再生材料和支架,以减轻骨质损失.
- 关于它们在减少放射性骨再吸收方面的有效性的证据需要合成.
研究的目的:
- 评估再生材料的有效性,有或没有脚手架,在提取后保持膜骨高度和宽度.
- 为了比较不同的再生疗法,包括血源生长因子,L-血小板丰富纤维素 (L-PRF) 和复合人体BMP-2 (rhBMP-2).
主要方法:
- 从2010年1月到2023年12月的英语人体研究的系统审查和元分析.
- 在PubMed,EMBASE,MEDLINE,Cochrane CENTRAL,Google Scholar和手动期刊搜索中进行的搜索.
- 进行了六次元分析,包括对L-PRF和rhBMP-2的单独分析;使用Cochrane标准评估偏差风险.
主要成果:
- 包括29篇涉及1068名参与者的文章.
- 血源制剂显示显著的高度保存,但没有显著的宽度保存.
- 再组合的人类BMP-2 (rhBMP-2) 与自然愈合相比,显著降低了水平和垂直骨再吸收.
- rhBMP-2在宽度保护方面比L-PRF更优越,但在高度保护方面却没有.
结论:
- 再生材料通常有利于牙拔除后的放射性骨宽度和高度的保存.
- rhBMP-2在膜宽度保护方面表现出卓越的有效性.
- 富含L-血小板纤维素 (L-PRF) 是一种可行的,自主性的,具有成本效益的骨保存替代品.
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