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SAM-Krom生物监测研究显示,在丹麦,职业暴露在六价和增加的基因毒性

Anne Thoustrup Saber¹, Marcus Levin², Pete Kines¹

¹National Research Centre for the Working Environment, 105 Lersø Parkallé, DK-2100, Copenhagen Ø, Denmark.

International journal of hygiene and environmental health

|September 24, 2024

概括

在丹麦,职业暴露于六价 (Cr(VI)) 是一个令人担忧的问题,特别是在浴上,由高的生物标志物表明. 需要进一步的控制来减少Cr (VI) 暴露,特别是考虑到潜在的非空中航线.

科学领域:

职业健康职业健康职业健康
环境毒理学环境毒理学
生物监测生物监测

背景情况:

六价 (Cr(VI)) 是一种已知的致癌物质,在和不钢接等行业具有职业暴露风险.
评估丹麦工人的Cr (VI) 暴露水平和相关健康风险对于实施有效的安全措施至关重要.

研究的目的:

评估在丹麦的工人和学徒中对六价 (Cr) 的职业暴露.
评估Cr (VI) 暴露环境中的职业安全和健康 (OSH) 风险预防措施的有效性.

主要方法:

一项涉及28名工人,8名学徒和24名来自6家公司和一所职业学校的对照者的横截面研究.
通过采访,问卷和观察评估工作安全与安全措施;测量空气中的Cr (VI) 和总.
尿液和红细胞 (RBC) 中的生物监测,以及通过网状细胞中微核 (MNRET) 的基因毒性评估.

主要成果:

在浴涂料中观察到高水平的OHS措施遵守,但在不钢接中观察到的较少.
在学徒 (3.69μg/m3) 和浴公司 (0.81μg/m3) 中发现了高的Cr{VI}的几何平均空气度.
与对照组相比,暴露于Cr(VI) 的工人表现出尿中的Cr,RBC中的Cr和MNRET水平显著更高,特别是在浴中.

结论:

浴表现出高Cr(VI) 暴露,由高生物标志物证明,超过既定极限值,并建议非空气传播的暴露途径.
虽然接工人没有显著增加,但他们的Cr水平与其他欧洲研究相当.
尽管观察到OHS合规性,但生物标志物数据表明坚持的变化,强调需要改进控制,包括消除,替代和自动化,以减少CrVI暴露.

关键词:

浴室盘子浴室盘子生物标志物生物标志物六价的六价是一种职业暴露的极限值是什么职业学校的职业学校是专业学校.接接接在

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