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乳腺癌患者接受化疗与或没有放射治疗的生命质量结果
Ryan T Morse1, Nathan W Bean2, Jacob Hall1
1Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.
辅助放射治疗对接受化疗的乳腺癌患者大多数生活质量 (QOL) 领域没有显著影响. 总体质量生活得分仍然不劣,为治疗决策提供了关键数据.
科学领域:
- 在瘤学瘤学.
- 生活质量研究 研究 生命质量研究
- 临床试验 临床试验
背景情况:
- 系统疗法改善了乳腺癌的瘤结果.
- 了解个别治疗组件对生活质量 (QOL) 的影响至关重要.
研究的目的:
- 调查辅助放射治疗是否对接受化疗的乳腺癌患者的QOL域产生显著影响.
- 假设辅助放射治疗不会显著影响QOL.
主要方法:
- 来自三项研究 (2014年3月至2019年12月) 的前性数据,涉及用化疗治疗的局部乳腺癌患者.
- 在基线和治疗后采集的患者报告的结果,使用慢性疾病治疗-疲劳 (FACIT-F) 的功能评估措施.
- 在接受放射治疗的患者与没有接受放射治疗的患者之间的QOL得分变化比较,使用单方面非劣势方法.
主要成果:
- 总共有175名患者被分析 (131人接受了辐射,44人没有).
- 大多数患者患有I-II阶段 (78%),激素受体阳性 (59%) 乳腺癌.
- 对于身体,社会/家庭和情感福祉,FACIT-疲劳子表和FACIT-F总得分 (p <0.05) 的平均QOL变化没有劣势.
- 功能福祉没有满足非劣等性标准 (p = 0.0594).
结论:
- 通过总FACIT-F得分来衡量患者报告的QOL,在接受放射治疗或不接受放射治疗的患者之间是非劣势的.
- 研究结果支持关于局部区域辐射对接受化疗的局部乳腺癌患者QOL的影响的知情决策.
- 单个QOL子尺度数据提供了对治疗效果的进一步了解.
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