与致病途径相关的尿路生物标志物反映了狼性炎中的组织学发现
Kazuoto Hiramoto1, Shuntaro Saito1, Hironari Hanaoka1
1Keio University School of Medicine, Tokyo, Japan.
Arthritis & rheumatology (Hoboken, N.J.)
|September 24, 2024
概括
尿路生物标志物calgranulin B,MCP-1和IGFBP-5可以预测狼性炎 (LN) 组织学严重程度. 这有助于了解LN病原体,并指导病的治疗决策.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 狼性炎 (LN) 病原和组织学严重性预测需要更好的理解.
- 确定可靠的生物标志物来预测LN组织学发现对于患者管理至关重要.
研究的目的:
- 在LN中识别致病信号通路.
- 发现尿路生物标志物,用于预测LN的组织学发现的存在和严重性.
主要方法:
- 基于Aptamer的蛋白质组测试选了1305种尿蛋白,这些蛋白质来自活检证明有活性的LN的患者.
- 分析了尿蛋白与量化组织学特征的关联.
- 候选生物标志物在单独的队列中得到验证,免疫组织化学证实了组织中的蛋白质定位.
主要成果:
- 集群分析在LN中确定了五个不同的组织学子组,每一个都与特定的致病途径有关.
- 尿中的calgranulin B (S100A9),单细胞化疗蛋白1 (MCP-1) 和类似胰岛素的生长因子结合蛋白5 (IGFBP-5) 水平与膜病变,间歇性炎症和纤维化相关.
- 免疫组织化学证实了这些蛋白质在相应的病变中的定位.
结论:
- 截然不同的致病机制是LN的不同病变的基础.
- 尿中的卡尔格拉努林B,MCP-1和IGFBP-5水平是LN组织学发现的存在和严重性的有价值预测指标.
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