晚期血管衰老和急性缺血性中风后的结果:系统性审查和元分析
Nikolaos Kakaletsis1,2, Athanase D Protogerou3, Vasilios Kotsis4
1Second Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. kakaletsisnikos@yahoo.gr.
Journal of human hypertension
|September 24, 2024
概括
脉冲波速度 (PWV) 表明动脉硬和血管衰老,预测急性缺血性中风 (AIS) 患者的不良结果. 较高的PWV水平与功能衰退,死亡率和中风复发的风险增加有关.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 脉冲波速度 (PWV) 是动脉硬和血管衰老的经过验证的生物标志物.
- 动脉硬性在预测心血管事件方面超过了传统的风险因素.
- 评估血管衰老对于治疗急性缺血性中风 (AIS) 患者至关重要.
研究的目的:
- 为了研究急性缺血性中风 (AIS) 患者的脉冲波速度 (PWV) 值.
- 评估PWV在AIS中的临床结果的预后价值.
- 确定动脉硬与AIS后不良事件之间的关联.
主要方法:
- 对2024年1月之前发表的研究进行了元分析.
- 分析了35项符合条件的研究 (11,953名baPWV患者,2,197名cfPWV患者) 的数据.
- 九项队列研究 (6,006名患者) 量化评估了临床结果.
主要成果:
- 较高的PWV水平与较差的功能结果显著相关 (2.3 m/s高,p < 0.001).
- 患有动脉硬度 (较高PWV) 的AIS患者显示,功能性结果差的风险增加了46.2%.
- 死亡率 (12.7%),主要心血管不良事件 (13.9%) 和中风复发 (13.9%) 的风险增加.
结论:
- 先进的血管衰老,以升高的PWV表示,是AIS患者不良结果的重要预测因素.
- 在临床实践中,PWV评估可以改善风险分层和患者管理.
- 整合血管衰老评估对于提高AIS幸存者的风险感知和指导干预至关重要.
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