在亚洲的低资源环境中,病原体基因组监测状态
Marya Getchell1, Suci Wulandari2, Ruklanthi de Alwis3,4,5
1Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Nature microbiology
|September 24, 2024
概括
亚洲 亚洲 亚洲 亚洲 亚洲
科学领域:
- 公共卫生 公共卫生
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 亚洲面临新兴传染病的重大风险,需要强有力的病原体监测.
- 有效地使用下一代测序 (NGS) 对于加强区域卫生安全至关重要.
- 评估目前在亚洲低资源环境中的病原体基因组监测能力是一个优先事项.
研究的目的:
- 开发和应用一个框架来评估病原体基因组监测能力在南亚和东南亚.
- 确定在低资源环境中的病原体监测中实施下一代测序的障碍和促进因素.
- 通过改进基因组监测,为加强区域卫生安全的战略提供信息.
主要方法:
- 开发了一种病原体基因组监测评估框架.
- 收集了2022年6月至2023年3月期间,来自南亚和东南亚13个国家的42个机构的数据.
- 评估机构能力,战略规划,NGS应用,并确定实施障碍.
主要成果:
- 病原体基因组学能力存在于所有被调查的国家,所有国家都有NGS能力.
- 七个国家有整合病原体基因组学的战略计划,但整体NGS利用是有限的,资源不足.
- NGS的应用主要集中在人类监测上,在环境和动物界面监测上使用有限;主要障碍包括资金,供应链,人员和质量保证.
结论:
- 虽然亚洲存在病原体基因组学能力,但由于资源限制和具体挑战,对监测的有效实施受到阻碍.
- 协调的区域努力对于支持国家规划,解决能力差距,改善质量保证和促进数据共享以进行知情决策至关重要.
- 加强基因组监测对于亚洲对新出现的传染病的准备至关重要.
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