Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What is the Immune System?01:38

What is the Immune System?

110.9K
Overview
110.9K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

3.8K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
3.8K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

536
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
536
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

771
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
771
Active versus Passive Immunity01:31

Active versus Passive Immunity

592
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
592
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

858
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
858

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Critical evaluation of the key mediators causing life-threatening symptoms during human anaphylaxis.

Drug discovery today·2026
Same author

Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates.

bioRxiv : the preprint server for biology·2026
Same author

Increased Constitutive Interferon-β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein.

European journal of immunology·2026
Same author

Lamprey <i>FOXN1</i> rescues the block of thymic epithelial cell development in the mouse <i>Foxn1</i>-deficient thymic rudiment.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Human diamine oxidase undergoes transcytosis and colocalizes with the plasma membrane monoamine transporter indicating intracellular histamine degradation.

European journal of cell biology·2025
Same author

Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells.

Nature communications·2025

相关实验视频

Updated: Jun 12, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

12.3K

通过比较免疫学了解脊椎动物免疫力.

Thomas Boehm1,2,3

  • 1Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. boehm@ie-freiburg.mpg.de.

Nature reviews. Immunology
|September 24, 2024
PubMed
概括

进化免疫学正在探索脊椎动物的多样性,以了解免疫功能. 这种比较方法可能会导致人类免疫系统疾病的新疗法.

科学领域:

  • 进化免疫学的进化免疫学
  • 进行比较的基因组学.
  • 脊椎动物生物学 脊椎动物生物学

背景情况:

  • 经典免疫学依赖于有限的模型物种.
  • 分子生物学和基因组学的进步使大规模研究成为可能.
  • 了解各种脊椎动物的免疫功能至关重要.

研究的目的:

  • 突出跨脊椎动物物种尚未探索的免疫现象.
  • 为了利用表型多样性对免疫功能的洞察力.
  • 建议进行比较研究,以测试免疫学假设.

主要方法:

  • 在6万种脊椎动物中对免疫系统进行比较分析.
  • 利用细胞生物学,基因组学和遗传修饰方面的进展.
  • 在可处理的模型生物中识别和测试假设.

主要成果:

  • 存在与免疫功能相关的重大尚未探索的生物现象.
  • 脊椎动物的表型多样性深刻影响免疫系统功能.
  • 对比研究可以揭示免疫力在进化过程中选择的变异.

结论:

更多相关视频

Comparative in vivo Study of gp96 Adjuvanticity in the Frog Xenopus laevis
11:20

Comparative in vivo Study of gp96 Adjuvanticity in the Frog Xenopus laevis

Published on: September 16, 2010

10.5K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.4K

相关实验视频

Last Updated: Jun 12, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

12.3K
Comparative in vivo Study of gp96 Adjuvanticity in the Frog Xenopus laevis
11:20

Comparative in vivo Study of gp96 Adjuvanticity in the Frog Xenopus laevis

Published on: September 16, 2010

10.5K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.4K
  • 探索脊椎动物的多样性为进化免疫学提供了新的途径.
  • 发现一般原则和变异可以激发新的治疗策略.
  • 未来的研究可以推进人类免疫系统疾病的治疗方法.