肉毒神经毒素A在持久性异常性牙气囊疼痛中的有效性:一个案例系列
Katia Rupel1, Florian Martina2, Ottaviani Giulia2
1Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 447 - 34129, Italy. krupel@units.it.
Clinical oral investigations
|September 24, 2024
概括
玻尿酸神经毒素-A (BONT-A) 在一系列病例中有效降低了持续性异常性牙气囊疼痛 (PIDP). 患者在BONT-A治疗后经历了显著的疼痛缓解和功能改善.
科学领域:
- 神经学 神经学
- 疼痛管理 疼痛管理
- 眼科医生 眼科 眼科
背景情况:
- 持久性异常性牙气囊疼痛 (PIDP) 是一个重大的临床挑战,有效治疗方法有限.
- 目前PIDP的管理策略主要基于症状,通常涉及局部或全身疗法.
- 玻尿酸神经毒素-A (BONT-A) 已成为各种疼痛条件的潜在治疗选择.
研究的目的:
- 评估肉毒神经毒素-A (BONT-A) 作为治疗持续性异常性牙气囊疼痛 (PIDP) 的疗效.
- 评估接受BONT-A治疗的PIDP患者的疼痛减轻和功能改善.
主要方法:
- 进行了涉及9名被诊断患有PIDP的患者的病例系列.
- 患者接受了BONT-A注射 (20-50U) 分布在口内和/或口外部位.
- 在基线和3个月内使用数值评分表 (NRS) 评估疼痛严重程度.
主要成果:
- 平均基线疼痛强度为NRS 6,显著降低至1个月后的NRS 4,并在治疗后的2个月和3个月后的NRS 2.
- 在BONT-A注射后5-10天内观察到止痛作用.
- 报告了疾病和肌肉低血压等轻微不良反应;像和吞这样的功能变量也得到了改善.
结论:
- 玻尿酸神经毒素-A (BONT-A) 显示出作为一种有效的替代治疗方法来治疗持续性异常性牙气囊疼痛 (PIDP) 的潜力.
- 在患有PIDP的患者中,BONT-A治疗导致了显著的疼痛减轻和功能改善.
- 需要进一步的研究来阐明作用机制,并优化PIDP的BONT-A治疗方案.
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