自然产品促进血管健康
Valérie B Schini-Kerth1, Ibrahima Diouf2, Hira Muzammel2
1Translational Cardiovascular Medicine, UR 3074, CRBS, University of Strasbourg, Strasbourg, France. valerie.schini-kerth@unistra.fr.
Handbook of experimental pharmacology
|September 24, 2024
概括
自然产品,特别是富含多的食物,通过改善内皮功能和降低心血管疾病风险,在衰老过程中支持血管健康. 这些化合物促进氧化的产生,并对抗细胞衰老.
科学领域:
- 心血管科学 心血管科学
- 衰老研究研究 衰老研究
- 营养科学 营养科学
背景情况:
- 血管健康对于健康的衰老和预防心血管疾病至关重要.
- 内皮功能障碍,标志着氧化 (NO) 生产受损和氧化应激增加,是与年龄有关的心血管问题的关键因素.
- 内皮老化是与年龄相关的内皮功能障碍中出现的早期事件.
研究的目的:
- 探索天然产品,特别是富含多的食物在促进衰老期间血管健康方面的作用.
- 研究这些天然产品对内皮功能,氧化 (NO) 生产和内皮衰老的影响.
- 评估饮食中摄入多的潜力,以预防或改善内皮功能障碍.
主要方法:
- 对自然产品和血管健康的临床前研究和人类数据的审查.
- 分析聚醇影响内皮细胞的机制,包括NO的形成和衰老.
- 检查聚醇摄入量与心血管疾病结局之间的关联.
主要成果:
- 临床前研究表明,富含多的食物激活了内皮通路,增加了NO的产生和依赖内皮的超极化.
- 一些天然产品对内皮老化表现出有益的影响.
- 某些富含多的产品与实验模型中的内皮功能障碍和人类心血管疾病的预防或改善有关.
结论:
- 饮食中摄入天然产品,特别是富含多的产品,是保持血管健康的有希望的策略.
- 这些产品提供了一种潜在的方法来抵消与年龄有关的内皮功能障碍,并降低心血管疾病的风险.
- 对特定的多机制和临床疗效的进一步研究对于优化血管健康干预措施是有必要的.
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