导航甲状腺-妇科相互作用:一个系统的审查和元分析
1Department of Pharmacy, Agamy Medical District, Ministry of Health and Population, Alexandria, Egypt.
Obstetrics & gynecology science
|September 25, 2024
概括
甲状腺功能低下症与各种妇科癌症有关,包括子宫癌. 然而,甲状腺功能障碍与卵巢癌死亡率的增加有关,因此需要进一步调查其作用.
科学领域:
- 内分泌学 在内分泌学.
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
背景情况:
- 甲状腺疾病越来越多地被认为与各种健康状况有关.
- 了解甲状腺功能障碍和妇科癌症之间的联系对于临床实践和患者的结果至关重要.
研究的目的:
- 系统地审查和分析现有的关于成年女性甲状腺疾病和妇科癌症之间的关联的文献.
- 在患有妇科癌症的妇女中量化甲状腺功能低下症和甲状腺功能增强症的患病率,并评估其风险.
- 评估甲状腺疾病对妇科癌症发病率和死亡率的影响.
主要方法:
- 在Scopus,科学网,PubMed和谷歌学者中进行了全面的文献搜索.
- 系统性审查和元分析是按照系统性审查和元分析 (PRISMA) 的首选报告项目指南进行的.
- 使用R 4.3.2和SPSS版本28进行了统计分析,包括赔率比率和风险比率.
主要成果:
- 包括19项研究,检查甲状腺状况与妇科癌症相关.
- 甲状腺功能低下症在13%的妇科癌症患者中存在,在研究中总体患病率为14%.
- 甲状腺功能低下症与子宫癌显著相关 (几率比为2.65),妇科癌症的风险比为1.3. 甲状腺功能障碍与卵巢癌死亡率增加有关 (风险比为2.14).
结论:
- 甲状腺功能低下症显著与患各种妇科癌症的风险增加有关,这表明甲状腺功能低下症可能在它们的发病过程中起作用.
- 甲状腺功能障碍与卵巢癌的死亡率增加有关.
- 需要进一步的研究,以阐明甲状腺功能障碍可能使女性易患卵巢癌的具体机制.
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